Observational, Multicenter Study on the Efficacy, Tolerability, and Safety of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis Older than 80 Years
Articolo
Data di Pubblicazione:
2023
Citazione:
Observational, Multicenter Study on the Efficacy, Tolerability, and Safety of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis Older than 80 Years / M. Mondoni, F. Alfano, F. Varone, G. Muscato, C. Conti, L. Saderi, A. Chiesa, F. DI MARCO, C. Vancheri, L. Richeldi, S. Centanni, G. Sotgiu. - In: RESPIRATION. - ISSN 0025-7931. - 102:1(2023 Jan), pp. 25-33. [10.1159/000527308]
Abstract:
Background: Idiopathic pulmonary fibrosis (IPF) primarily affects old patients. Old age is a predictor of mortality. Nintedanib, the only antifibrotic drug approved in Italy for patients aged >80 years, can slow the progression of IPF by reducing the rate of decline in forced vital capacity (FVC) and the risk of exacerbations.
Objectives: The primary aim of the study was to compare the decline of FVC after 12 months of nintedanib in patients aged >80 years versus younger patients. Differences related to other functional data, safety, tolerability, hospitalizations, exacerbations, and mortality were evaluated.
Methods: An observational, retrospective, multicenter study was carried out in Italy.
Results: 159 (122 [76.7%] males) patients were recruited: 106 (66.7%) aged ≤80 years and 53 (33.3%) aged >80 years. FVC decline after 12 months of therapy was not significantly different (-45 mL [-170; 75] vs. -20 mL [-138; 110] mL; p: 0.51). No differences were found for other functional data. Diarrhea was the most frequent adverse event (AE). Rate and type of any AEs, permanent/temporary dose reduction, or drug discontinuation were not significantly different between patients aged ≤80 vs. >80 years. Furthermore, acute exacerbations, hospitalization, and mortality were not significantly different.
Conclusions: Nintedanib is effective and safe in patients with IPF aged >80 years, and no significant differences were found when clinical outcomes were compared with those of younger patients. Thus, older age should not be a barrier for the early prescription of antifibrotic treatment in IPF patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antifibrotic therapy; Elderly; Exacerbation; Idiopathic pulmonary fibrosis; Nintedanib; Safety;
Elenco autori:
M. Mondoni, F. Alfano, F. Varone, G. Muscato, C. Conti, L. Saderi, A. Chiesa, F. DI MARCO, C. Vancheri, L. Richeldi, S. Centanni, G. Sotgiu
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