The MCP-1 A-2518G polymorphism acts as proctective factor for frontotemporal lobar degeneration
Poster
Data di Pubblicazione:
2008
Citazione:
The MCP-1 A-2518G polymorphism acts as proctective factor for frontotemporal lobar
degeneration / C. Villa, E. Venturelli, C. Fenoglio, F. Clerici, A. Marcone, L. Benussi, F. Cortina, D. Scalabrini, L. Perini, G. Binetti, S. Cappa, C. Mariani, N. Bresolin, E. Scarpini, D. Galimberti. - In: CLINICAL NEUROPATHOLOGY. - ISSN 0722-5091. - 27:4(2008), pp. 285-285. (Intervento presentato al 44. convegno Congresso dell’Associazione Italiana di Neuropatologia (AINP) & Congresso dell’Associazione Italiana per la Ricerca sull’Invecchiamento Cerebrale (AIRIC) tenutosi a Milano nel 2008).
Abstract:
Increased levels ofMonocyteChemoattractant
Protein (MCP)-1 have
been found in cerebrospinal fluid from
patients with frontotemporal lobar degeneration
(FTLD), suggesting a role
in neurodegeneration. 209 patients
with sporadic FTLD were genotyped
for the A-2518G single nucleotide
polymorphism (SNP) in MCP-1 and
compared with 203 age-matched controls.
Asignificantly decreased allelic
frequency of theGallele in patients as
compared with controls was observed
(21.1 vs. 29.3%, p = 0.010, OR: 0.59,
CI: 0.40 – 0.87). Stratifying for gender,
the significance was reached in
males only, whereas no differences
were observed stratifying for ApoE
status. None of patients was a carrier
of mutations in progranulin gene.
Therefore, the A-2518G SNP likely
represent a protective factor for the
development of sporadic FTLD
Protein (MCP)-1 have
been found in cerebrospinal fluid from
patients with frontotemporal lobar degeneration
(FTLD), suggesting a role
in neurodegeneration. 209 patients
with sporadic FTLD were genotyped
for the A-2518G single nucleotide
polymorphism (SNP) in MCP-1 and
compared with 203 age-matched controls.
Asignificantly decreased allelic
frequency of theGallele in patients as
compared with controls was observed
(21.1 vs. 29.3%, p = 0.010, OR: 0.59,
CI: 0.40 – 0.87). Stratifying for gender,
the significance was reached in
males only, whereas no differences
were observed stratifying for ApoE
status. None of patients was a carrier
of mutations in progranulin gene.
Therefore, the A-2518G SNP likely
represent a protective factor for the
development of sporadic FTLD
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Villa, E. Venturelli, C. Fenoglio, F. Clerici, A. Marcone, L. Benussi, F. Cortina, D. Scalabrini, L. Perini, G. Binetti, S. Cappa, C. Mariani, N. Bresolin, E. Scarpini, D. Galimberti
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