Data di Pubblicazione:
2022
Citazione:
Curcumin-based ionic Pt(ii) complexes: antioxidant and antimicrobial activity / R. Caligiuri, G. Di Maio, N. Godbert, F. Scarpelli, A. Candreva, I. Rimoldi, G. Facchetti, M.G. Lupo, E. Sicilia, G. Mazzone, F. Ponte, I. Romeo, M. La Deda, A. Crispini, R. De Rose, I. Aiello. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - 51:43(2022 Nov 08), pp. 16545-16556. [10.1039/d2dt01653b]
Abstract:
A series of novel cationic curcumin-based Pt(ii) complexes with neutral (N^N) ligands and triflate anions as counterions, [(N^N)Pt(curc)]CF3SO3, 1-4, were synthesised and fully characterised. The antioxidant radical scavenging activity of complexes 1-4 was measured spectrophotometrically using DPPH as the internal probe. Computational strategies have been exploited to ascertain the mechanism of antioxidant action of curcumin (H(curc)) and its Pt(ii) complexes. Finally, compounds 1-4 were tested in vitro for their growth inhibitory activity against two bacteria (Staphylococcus aureus and Escherichia coli) by the disk diffusion technique at different Pt(ii) complex solution concentrations. The effect of the complexation of H(curc) was investigated.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antioxidants; Bacteria; Curcumin; Coordination Complexes; Anti-Infective Agents;
Elenco autori:
R. Caligiuri, G. Di Maio, N. Godbert, F. Scarpelli, A. Candreva, I. Rimoldi, G. Facchetti, M.G. Lupo, E. Sicilia, G. Mazzone, F. Ponte, I. Romeo, M. La Deda, A. Crispini, R. De Rose, I. Aiello
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