Data di Pubblicazione:
2008
Citazione:
Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels / U. Schenk, A.M. Westendorf, E. Radaelli, A. Casati, M. Ferro, M. Fumagalli, C. Verderio, J. Buer, E. Scanziani, F.M. Grassi. - In: SCIENCE SIGNALING. - ISSN 1937-9145. - 1:39(2008 Sep 30), pp. ra6.ra6.1-ra6.ra6.12. [10.1126/scisignal.1160583]
Abstract:
T cell receptor (TCR) stimulation results in the influx of Ca(2+), which is buffered by mitochondria and promotes adenosine triphosphate (ATP) synthesis. We found that ATP released from activated T cells through pannexin-1 hemichannels activated purinergic P2X receptors (P2XRs) to sustain mitogen-activated protein kinase (MAPK) signaling. P2XR antagonists, such as oxidized ATP (oATP), blunted MAPK activation in stimulated T cells, but did not affect the nuclear translocation of the transcription factor nuclear factor of activated T cells, thus promoting T cell anergy. In vivo administration of oATP blocked the onset of diabetes mediated by anti-islet TCR transgenic T cells and impaired the development of colitogenic T cells in inflammatory bowel disease. Thus, pharmacological inhibition of ATP release and signaling could be beneficial in treating T cell-mediated inflammatory diseases.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
U. Schenk, A.M. Westendorf, E. Radaelli, A. Casati, M. Ferro, M. Fumagalli, C. Verderio, J. Buer, E. Scanziani, F.M. Grassi
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