Data di Pubblicazione:
2023
Citazione:
Photo-Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles / P. Perez Schmidt, K. Pagano, C. Lenardi, M. Penconi, R. MATEU FERRANDO, C. Evangelisti, L. Lay, L. Ragona, M. Marelli, L. Polito. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 62:1(2023 Jan 02), pp. e202210140.1-e202210140.6. [10.1002/anie.202210140]
Abstract:
Ultra-small gold nanoparticles (UAuNPs) are extremely
interesting for applications in nanomedicine thanks to their good
stability, biocompatibility, long circulation time and efficient
clearance pathways. UAuNPs engineered with glycans (Glyco-
UAuNPs) emerged as excellent platforms for many applications
since the multiple copies of glycans can mimic the multivalent
effect of glycoside clusters. Herein, we unravel a straightforward
photo-induced synthesis of Glyco-UAuNPs based on a reliable
and robust microfluidic approach. The synthesis occurs at room
temperature avoiding the use of any further chemical reductant,
templating agents or co-solvents. Exploiting 1H-NMR
spectroscopy, we showed that the amount of thiol-ligand exposed
on the UAuNPs is linearly correlated to the ligand concentration
in the initial mixture. The results pave the way towards the
development of a programmable synthetic approach, enabling an
accurate design of the engineered UAuNPs or smart hybrid nano-
systems.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P. Perez Schmidt, K. Pagano, C. Lenardi, M. Penconi, R. MATEU FERRANDO, C. Evangelisti, L. Lay, L. Ragona, M. Marelli, L. Polito
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