Data di Pubblicazione:
2008
Citazione:
Enzymatic synthesis of ω-carboxy-β-hydroxy-(L)-α-amino acids / F. Sagui, P. Conti, G. Roda, R. Contestabile, S. Riva. - In: TETRAHEDRON. - ISSN 0040-4020. - 64:22(2008), pp. 5079-5084.
Abstract:
Commercially available ω-carboxy-aldehydes and glycine have been subjected to the catalytic action of an l-threonine aldolase from Escherichia coli to give the corresponding β-hydroxy-α-(l)-amino acids as a mixture of erythro/threo epimers.
Specifically, the reaction with glyoxylic acid (2) gave the epimeric β-hydroxy-(l)-aspartates (t,e)-9 that could be isolated by ion-exchange chromatography in 67% yield. Following esterification and N-Boc protection, the two epimers could be isolated as pure compounds.
Similarly, the aldolase-catalyzed addition of glycine to succinic semialdehyde (4) gave the expected mixture of β-hydroxy-l-α-aminoadipic acids (t)-12 and (e)-12 in 34% yield
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F. Sagui, P. Conti, G. Roda, R. Contestabile, S. Riva
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