The chronotopic™ system for pulsatile and colonic delivery of active molecules in the era of precision medicine: Feasibility by 3D printing via fused deposition modeling (fdm)
Articolo
Data di Pubblicazione:
2021
Citazione:
The chronotopic™ system for pulsatile and colonic delivery of active molecules in the era of precision medicine: Feasibility by 3D printing via fused deposition modeling (fdm) / A. Melocchi, M. Uboldi, F. Briatico-Vangosa, S. Moutaharrik, M. Cerea, A. Foppoli, A. Maroni, L. Palugan, L. Zema, A. Gazzaniga. - In: PHARMACEUTICS. - ISSN 1999-4923. - 13:5(2021 May 20), pp. 759.1-759.18. [10.3390/pharmaceutics13050759]
Abstract:
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configuration, entailing a gastroresistant film to prevent early interaction of the inner coat with gastric fluids and enabling the attainment of a lag phase matching the small intestinal transit time. Over the years, various multiple-step manufacturing processes have been tested for the fabrication of the Chronotopic™ system in both its configurations. This work focused on the evaluation of 3D printing by fused deposition modeling in view of its potential towards product personalization, on demand one-step manufacturing and efficient scale down of batches. The feasibility of each part of the Chronotopic™ system was independently investigated starting from in-house made filaments, characterizing the resulting specimens for physico-technological and performance characteristics. The printing parameters identified as suitable during the set-up phase were then used to fabricate prototypes either in a single step for the pulsatile configuration or following two different fabrication approaches for the colon-targeting one.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
3D printing; Chronopharmaceu-tics; Colon targeting; Controlled release; Fused deposition modeling; Multi-component systems; Pulsatile release;
Elenco autori:
A. Melocchi, M. Uboldi, F. Briatico-Vangosa, S. Moutaharrik, M. Cerea, A. Foppoli, A. Maroni, L. Palugan, L. Zema, A. Gazzaniga
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