Synthesis and characterization of curcumin-loaded nanoparticles of poly(glycerol sebacate) : a novel highly stable anticancer system
Articolo
Data di Pubblicazione:
2022
Citazione:
Synthesis and characterization of curcumin-loaded nanoparticles of poly(glycerol sebacate) : a novel highly stable anticancer system / A. Massironi, S. Marzorati, A. Marinelli, M. Toccaceli, S. Gazzotti, M.A. Ortenzi, D. Maggioni, K. Petroni, L. Verotta. - In: MOLECULES. - ISSN 1420-3049. - 27:20(2022 Oct 18), pp. 6997.1-6997.18. [10.3390/molecules27206997]
Abstract:
The research for alternative administration methods for anticancer drugs, towards enhanced
effectiveness and selectivity, represents a major challenge for the scientific community. In
the last decade, polymeric nanostructured delivery systems represented a promising alternative to
conventional drug administration since they ensure secure transport to the selected target, providing
active compounds protection against elimination, while minimizing drug toxicity to non-target cells.
In the present research, poly(glycerol sebacate), a biocompatible polymer, was synthesized and then
nanostructured to allow curcumin encapsulation, a naturally occurring polyphenolic phytochemical
isolated from the powdered rhizome of Curcuma longa L. Curcumin was selected as an anticancer
agent in virtue of its strong chemotherapeutic activity against different cancer types combined with
good cytocompatibility within healthy cells. Despite its strong and fascinating biological activity,
its possible exploitation as a novel chemotherapeutic has been hampered by its low water solubility,
which results in poor absorption and low bioavailability upon oral administration. Hence, its
encapsulation within nanoparticles may overcome such issues. Nanoparticles obtained through
nanoprecipitation, an easy and scalable technique, were characterized in terms of size and stability
over time using dynamic light scattering and transmission electron microscopy, confirming their
nanosized dimensions and spherical shape. Finally, biological investigation demonstrated an enhanced
cytotoxic effect of curcumin-loaded PGS-NPs on human cervical cancer cells compared to
free curcumin.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
curcumin; poly(glycerol sebacate); nanoparticles; drug delivery system; human cervical cancer
Elenco autori:
A. Massironi, S. Marzorati, A. Marinelli, M. Toccaceli, S. Gazzotti, M.A. Ortenzi, D. Maggioni, K. Petroni, L. Verotta
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