Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631
Articolo
Data di Pubblicazione:
2008
Citazione:
Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631 / L. Sironi, J.L. Williams, A.M. Moreno-Martin, P. Ramelli, A. Stella, H. Jianlin, S. Weigend, G. Lombardi, P. Cordioli, P. Mariani. - In: VIROLOGY. - ISSN 0042-6822. - 380:1(2008 Oct 10), pp. 152-156.
Abstract:
Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Avian influenza; Chicken experimental infection; Highly pathogenic H7N1; Mx gene; Resistance
Elenco autori:
L. Sironi, J.L. Williams, A.M. Moreno-Martin, P. Ramelli, A. Stella, H. Jianlin, S. Weigend, G. Lombardi, P. Cordioli, P. Mariani
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