Data di Pubblicazione:
2008
Citazione:
Diazepam protects against the enhanced toxicity of cocaine adulterated with atropine / D. Braida, A. Zani, V. Capurro, G. Rossoni, S. Pegorini, E. Gori, M. Sala. - In: JOURNAL OF PHARMACOLOGICAL SCIENCES. - ISSN 1347-8613. - 107:4(2008 Aug), pp. 408-418.
Abstract:
We examined the toxicity of cocatropine (cocaine/atropine mixture) and the therapeutic potential of diazepam on some behavioral and physiological parameters in rats. Atropine (20 and 60 mg/kg) or cocaine (40 mg/kg) alone did not induce any seizure or death, but the combination significantly increased both, after both acute and binge treatment. There was a significant increase of EEG mean total spectral power in cocatropine- in comparison with cocaine-treated animals. Hyperlocomotion was observed in non-seizuring rats treated with cocaine or cocatropine. Cocaine, atropine 60, and cocatropine (40 + 20 and 40 + 60) all induced hyperthermic effects in non-seizuring rats, while cocatropine (40 + 60)-seizuring animals had hypothermia. An initial hypertensive and tachycardiac effect within 15 min was followed by a secondary fall in the cocatropine (40 + 60) group. Cocatropine toxicity was partially or fully reversed by diazepam (5 mg/kg), given intraperitoneally after the first seizure. The present findings provide, for the first time, details of a synergistic toxic effect of the cocaine/atropine mixture and of the potential of diazepam for treating cocatropine-related hospital emergencies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Anticholinergic; Behavior; Binge; Crystalline; Drug abuse
Elenco autori:
D. Braida, A. Zani, V. Capurro, G. Rossoni, S. Pegorini, E. Gori, M. Sala
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