Evaluating the association between blood genotype or phenotype and haemoplasma infection in UK and Italian cats
Articolo
Data di Pubblicazione:
2022
Citazione:
Evaluating the association between blood genotype or phenotype and haemoplasma infection in UK and Italian cats / E. Spada, P. Galluzzo, A. Torina, G.R. Loria, R. Perego, F. Grippi, V. Blanda, L. Baggiani, A. D'Amico, M.G. Pennisi, C.R. Helps, R. Malik, M. Westman, B. Gandolfi, S. Spencer, D. Proverbio, S. Tasker. - In: THE VETERINARY RECORD. - ISSN 0042-4900. - (2022), pp. e2282.1-e2282.9. [Epub ahead of print] [10.1002/vetr.2282]
Abstract:
Background: In humans, blood groups are associated with varying preva- lence of infections. The aim of this study was to determine if associations exist between the feline AB blood group system and haemoplasma infection. Methods: Data from two studies were combined. In the first study, DNA sam- ples from 131 haemoplasma-infected and 132 haemoplasma-uninfected UK cats underwent pyrosequencing to determine their blood genotype as AA, Ab or bb. In the second study, blood samples from 160 Italian cats of known blood phenotype A, B or AB underwent PCR testing for feline haemoplasma species DNA.
Results: Haemoplasma infection was demonstrated in cats of all phenotypes and genotypes. A significantly higher number of Ab genotype cats tested pos- itive for overall haemoplasma infection status (p = 0.04) and for Mycoplasma haemofelis infection (p = 0.03).
Limitations: Haemoplasma-infected Italian cats were few, possibly increas- ing the chance of type II error, and the presence of purebred cats in the sample population may have had a confounding effect.
Conclusions: Feline haemoplasmas do not appear to preferentially use either blood type A or B antigens as attachment sites for erythrocyte colonisation. Further investigations in a larger number of haemoplasma-infected cats of known blood phenotype are warranted to explain the association between genotype Ab and haemoplasma infection.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
AB group system; blood type; feline; haemotropic mycoplasma; infections;
Elenco autori:
E. Spada, P. Galluzzo, A. Torina, G.R. Loria, R. Perego, F. Grippi, V. Blanda, L. Baggiani, A. D'Amico, M.G. Pennisi, C.R. Helps, R. Malik, M. Westman, B. Gandolfi, S. Spencer, D. Proverbio, S. Tasker
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