Data di Pubblicazione:
2022
Citazione:
The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? / A. Aveta, C. Cacciapuoti, B. Barone, E.D. Di Zazzo, F.D. Del Giudice, M. Maggi, M. Ferro, D. Terracciano, G.M. Busetto, G. Lucarelli, O.S. Tataru, E. Montanari, B.F. Mirto, A. Falcone, G. Giampaglia, E. Sicignano, F. Capone, G. Villano, P. Angellotto, C. Manfredi, L. Napolitano, C. Imbimbo, S.D. Pandolfo, F. Crocetto. - In: CANCERS. - ISSN 2072-6694. - 14:19(2022), pp. 4775.1-4775.15. [10.3390/cancers14194775]
Abstract:
Bladder cancer (BC) represents the second most common genitourinary malignancy. The
major risk factors for BC include age, gender, smoking, occupational exposure, and infections. The
BC etiology and pathogenesis have not been fully defined yet. Since catabolites are excreted through
the urinary tract, the diet may play a pivotal role in bladder carcinogenesis. Meat, conventionally
classified as “red”, “white” or “processed”, represents a significant risk factor for chronic diseases
like cardiovascular disease, obesity, type 2 diabetes, and cancer. In particular, red and processed
meat consumption seems to increase the risk of BC onset. The most accepted mechanism proposed
for explaining the correlation between meat intake and BC involves the generation of carcinogens,
such as heterocyclic amines and polycyclic aromatic hydrocarbons by high-temperature cooking.
This evidence claims the consumption limitation of meat. We reviewed the current literature on
potential biological mechanisms underlying the impact of meat (red, white, and processed) intake
on the increased risk of BC development and progression. Toward this purpose, we performed an
online search on PubMed using the term “bladder cancer” in combination with “meat”, “red meat”, “white meat” or “processed meat”. Although some studies did not report any association between
BC and meat intake, several reports highlighted a positive correlation between red or processed
meat intake, especially salami, pastrami, corned beef and bacon, and BC risk. We speculate that a
reduction or rather a weighting of the consumption of red and processed meat can reduce the risk
of developing BC. Obviously, this remark claims future indications regarding food education (type
of meat to be preferred, quantity of red meat to be eaten and how to cook it) to reduce the risk of
developing BC. Further well-designed prospective studies are needed to corroborate these findings.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
bladder cancer; red meat; processed meat; white meat; prevention; diet; carcinogenesis;
Elenco autori:
A. Aveta, C. Cacciapuoti, B. Barone, E.D. Di Zazzo, F.D. Del Giudice, M. Maggi, M. Ferro, D. Terracciano, G.M. Busetto, G. Lucarelli, O.S. Tataru, E. Montanari, B.F. Mirto, A. Falcone, G. Giampaglia, E. Sicignano, F. Capone, G. Villano, P. Angellotto, C. Manfredi, L. Napolitano, C. Imbimbo, S.D. Pandolfo, F. Crocetto
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