Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes
Articolo
Data di Pubblicazione:
2022
Citazione:
Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes / D. Malpicci, S. Andolina, S. Di Ciolo, E. Lucenti, E. Cariati, S. Marzano, B. Pagano, J. Amato, A. Randazzo, C. Giannini. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2022:35(2022 Sep 20), pp. e202200718.1-e202200718.9. [10.1002/ejoc.202200718]
Abstract:
The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aminoguanidine; Cyclic triimidazole; G-quadruplex; Ligand design; N-methylated pyridine;
Elenco autori:
D. Malpicci, S. Andolina, S. Di Ciolo, E. Lucenti, E. Cariati, S. Marzano, B. Pagano, J. Amato, A. Randazzo, C. Giannini
Link alla scheda completa: