Obstructive sleep apnea and right ventricular function: A meta-analysis of speckle tracking echocardiographic studies
Articolo
Data di Pubblicazione:
2022
Citazione:
Obstructive sleep apnea and right ventricular function: A meta-analysis of speckle tracking echocardiographic studies / M. Tadic, E. Gherbesi, A. Faggiano, C. Sala, S. Carugo, C. Cuspidi. - In: THE JOURNAL OF CLINICAL HYPERTENSION. - ISSN 1524-6175. - 24:10(2022), pp. 1247-1254. [10.1111/jch.14550]
Abstract:
The authors investigated the association between obstructive sleep apnea (OSA)
and right ventricular (RV) systolic dysfunction trough a meta-analysis of echocardio-
graphic studies providing data on RV mechanics as assessed by longitudinal strain (LS).
A systematic search was conducted using PubMed, OVID-MEDLINE, and Cochrane
library databases to search English-language review papers published from inception
to March 31, 2022. Only studies reporting data on RV free-wall or global LS in patients
with OSA of different severity and non-OSA controls were reviewed. Data of interest
were pooled to obtain standard means difference (SMD) with 95% confidence inter-
val (CI). The meta-analysis included 628 participants (436 with OSA and 192 controls)
from eight studies. Compared to controls, RV free wall LS was significantly reduced in
the pooled OSA group (SMD 1.02 ± .33, CI:.17/1.24, P < .002); this was also the case for
RV global LS (SMD: .72 ± .11, CI: .50/.93, P < .0001). Notably, compared to patients with
mild-OSA those with moderate and severe OSA exhibited significantly lower RV free-
wall LS and global LS values; this was not the case for tricuspid annular plane excursion.
In conclusions, both RV free-wall and global LS are impaired in patients with OSA; dete-
rioration of these indices, unlike TAPSE, was already evident in the early stages and was
related to the severity of the syndrome. Thus, RV myocardial strain should be consid-
ered to be included in echocardiographic evaluation of OSA patients in order to detect
subclinical cardiac damage in these patients regardless of its degree of severity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
meta-analysis; obstructive sleep apnea; right ventricular strain; tricuspid annular plane excursion
Elenco autori:
M. Tadic, E. Gherbesi, A. Faggiano, C. Sala, S. Carugo, C. Cuspidi
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