Effectiveness and Safety of Upadacitinib in the Treatment of Moderate-Severe Atopic Dermatitis: A Multicentric, Prospective, Real-World, Cohort Study
Articolo
Data di Pubblicazione:
2022
Citazione:
Effectiveness and Safety of Upadacitinib in the Treatment of Moderate-Severe Atopic Dermatitis: A Multicentric, Prospective, Real-World, Cohort Study / A. Chiricozzi, N. Gori, A. Narcisi, A. Balato, A. Gambardella, M. Ortoncelli, A.V. Marzano, R. Balestri, G. Palazzo, M. Pellegrino, M. Romanelli, G. Tripepi, K. Peris, A. Costanzo. - In: DRUGS IN R&D. - ISSN 1174-5886. - 22:(2022 Sep), pp. 245-252. [10.1007/s40268-022-00396-1]
Abstract:
Background The efficacy and safety of upadacitinib in atopic dermatitis (AD) have been defined in clinical trials, but no real-world data are currently available. We aimed to assess the safety and effectiveness of upadacitinib in a real-world AD patient cohort that mostly included patients who failed the available systemic therapies, including dupilumab. Methods Prospective cohort study collecting data on upadacitinib-treated AD adult patients completing at least 16 weeks of therapy. Results Forty-three patients showed rapid and marked response to upadacitinib with significant reduction of all disease severity scores since the first follow-up visit. At week 16, Eczema Area and Severity Index (EASI) 75, EASI 90, and EASI 100 response was observed in 97.5%, 82.1%, and 69.2% of patients, respectively. EASI 90 response reflected the achievement of a clear or almost clear condition (POEM 0-2), self-evaluated by 79.5% of patients. Patients' quality of life improved as suggested by the achievement of DLQI 0/1 by 38.5% of patients at week 4, and by 76.9% at week 16. Conclusion Elevated effectiveness and favorable safety of upadacitinib were confirmed in patients unresponsive to dupilumab, who were not included in upadacitinib trials.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Chiricozzi, N. Gori, A. Narcisi, A. Balato, A. Gambardella, M. Ortoncelli, A.V. Marzano, R. Balestri, G. Palazzo, M. Pellegrino, M. Romanelli, G. Tripepi, K. Peris, A. Costanzo
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