Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome
Articolo
Data di Pubblicazione:
2008
Citazione:
Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome / M. Yeganeh, P. Henneke, N. Rezaei, S. Ehl, D. Thiel, N. Matamoros, M.C. Pietrogrande, T. Espanol, J. Litzman, J. Franco, O. Sanal, S. Kilic, A. Breborowicz, A. Plebani, E. Renner, S. Rothenfusser, T. Hawn, C. Woellner, B. Grimbacher. - In: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. - ISSN 1018-2438. - 146:3(2008), pp. 190-194. [10.1159/000115886]
Abstract:
Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-α and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES. Copyright
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Yeganeh, P. Henneke, N. Rezaei, S. Ehl, D. Thiel, N. Matamoros, M.C. Pietrogrande, T. Espanol, J. Litzman, J. Franco, O. Sanal, S. Kilic, A. Breborowicz, A. Plebani, E. Renner, S. Rothenfusser, T. Hawn, C. Woellner, B. Grimbacher
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