The role of gender in a large international OCD sample: A Report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) Network
Articolo
Data di Pubblicazione:
2022
Citazione:
The role of gender in a large international OCD sample: A Report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) Network / B. Benatti, N. Girone, L. Celebre, M. Vismara, E. Hollander, N.A. Fineberg, D.J. Stein, H. Nicolini, N. Lanzagorta, D. Marazziti, S. Pallanti, M. van Ameringen, C. Lochner, O. Karamustafalioglu, L. Hranov, M. Figee, L.M. Drummond, J.E. Grant, D. Denys, L.F. Fontenelle, J.M. Menchon, J. Zohar, C.I. Rodriguez, B. Dell'Osso. - In: COMPREHENSIVE PSYCHIATRY. - ISSN 0010-440X. - 116:(2022 Jul), pp. 152315.1-152315.5. [10.1016/j.comppsych.2022.152315]
Abstract:
Introduction: Obsessive-compulsive disorder (OCD) is characterized by a range of phenotypic expressions. Gender may be a relevant factor in mediating the disorder's heterogeneity. The aim of the present report was to explore a large multisite clinical sample of OCD patients, hypothesizing existing demographic, geographical and clinical differences between male and female patients with OCD.& nbsp;Methods: Socio-demographic and clinical variables of 491 adult OCD outpatients recruited in the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network were investigated with a retrospective analysis on a previously gathered set of data from eleven countries worldwide. Patients were assessed throughstructured clinical interviews, the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Montgomery-Asberg Depression Rating Scale (MADRS) and the Self-rating Depression Scale (SDS).& nbsp;Results: Among females, adult onset (> 18 years old) was significantly over-represented (67% vs. 33%, p < 0.005), and females showed a significantly older age at illness onset compared with males (20.85 +/- 10.76 vs. 17.71 +/- 8.96 years, p < 0.005). Females also had a significantly lower education level than males (13.09 +/- 4.02 vs. 13.98 +/- 3.85 years; p < 0.05), a significantly higher rate of being married (50.8% vs. 33.5%; p < 0.001) and a higher rate of living with a partner (47.5% vs. 37.6%; p < 0.001) than males. Nonetheless, no significant gender dif-ferences emerged in terms of the severity of OCD symptoms nor in the severity of comorbid depressive symptoms. No predictive effect of gender was found for Y-BOCS, MADRS and SDS severity.& nbsp;Discussion/Conclusions.: Our findings showed significant differences between genders in OCD. A sexually dimorphic pattern of genetic susceptibility may have a crucial role to OCD clinical heterogeneity, potentially requiring different specific therapeutic strategies. Further research is warranted to validate gender as an important determinant of the heterogeneity in OCD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Age at onset; Education; Gender differences; OCD; Adolescent; Adult; Comorbidity; Educational Status; Female; Humans; Male; Retrospective Studies; Compulsive Personality Disorder; Obsessive-Compulsive Disorder
Elenco autori:
B. Benatti, N. Girone, L. Celebre, M. Vismara, E. Hollander, N.A. Fineberg, D.J. Stein, H. Nicolini, N. Lanzagorta, D. Marazziti, S. Pallanti, M. van Ameringen, C. Lochner, O. Karamustafalioglu, L. Hranov, M. Figee, L.M. Drummond, J.E. Grant, D. Denys, L.F. Fontenelle, J.M. Menchon, J. Zohar, C.I. Rodriguez, B. Dell'Osso
Link alla scheda completa: