Data di Pubblicazione:
2022
Citazione:
Immunonutrition and SARS-CoV-2 Infection in Children with Obesity / E.C. D'Auria, V. Calcaterra, E. Verduci, M. Ghezzi, R. Lamberti, S. Vizzuso, P. Baldassarre, E. Pendezza, V. Perico, A. Bosetti, G.V. Zuccotti. - In: NUTRIENTS. - ISSN 2072-6643. - 14:9(2022 May), pp. 1701.1-1701.21. [10.3390/nu14091701]
Abstract:
Since the beginning of the SARS-CoV-2 pandemic, there has been much discussion about the
role of diet and antiviral immunity in the context of SARS-CoV-2 infection. Intake levels of vitamins
D, C, B12, and iron have been demonstrated to be correlated with lower COVID-19 incidence and
mortality. Obesity has been demonstrated to be an independent risk for the severity of COVID-19
infection in adults and also in children. This may be due to different mechanisms, mainly including
the gut dysbiosis status observed in obese children. Moreover, the existence of a gut–lung axis
added new knowledge to on the potential mechanisms by which diet and dietary substances may
affect immune function. The aim of this narrative review is to address the intricate inter-relationship
between COVID-19, immune function, and obesity-related inflammation and to describe the role of
nutrients and dietary patterns in enhancing the immune system. Two ways to fight against COVID-19
disease exist: one with an antiviral response through immune system boosting and another with
antioxidants with an anti-inflammatory effect. In the current pandemic situation, the intake of a
varied and balanced diet, rich in micronutrients and bioactive compounds including fibers, should
be recommended. However, clinical studies conducted on children affected by SARS-CoV-2 infection
and comorbidity are warranted.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
SARS-CoV-2 infection; obesity; antiviral immunity; micronutrients; gut–lung axis; dysbiosis; immunonutrition
Elenco autori:
E.C. D'Auria, V. Calcaterra, E. Verduci, M. Ghezzi, R. Lamberti, S. Vizzuso, P. Baldassarre, E. Pendezza, V. Perico, A. Bosetti, G.V. Zuccotti
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