Data di Pubblicazione:
2008
Citazione:
Intracerebroventricular capsaicin influences the body weight increasing of rats / M. Falchi, A. Bertelli, F. Ferrara, R. Galazzo, S. Galazzo, C. Gharib, B. Dib. - In: BRAIN RESEARCH BULLETIN. - ISSN 0361-9230. - 77:5(2008), pp. 253-256.
Abstract:
Adult rats were treated for ten days with capsaicin or with NaCl 0.9% directly injected into the lateral
cerebral ventricles through a surgically implanted cannula. A third group of rats was implanted with the
same cannula but did not receive any treatment. The food intake and the body weight were recorded
for at least six weeks after stopping the treatment. The animals were always kept at constant ambient
temperature of 22°C. The body weight of the capsaicin-treated group was reduced by the treatment, and
showed a regular but lower degree of recovery trend than the control groups after the treatment period. In
fact the capsaicin treated animals never reached the bodyweight of the controls.Nevertheless, food intake
did not significantly vary after the capsaicin treatment. On the basis of these and previous findings,we can
assume that capsaicin injected into the cerebral ventricles to rats kept at constant ambient temperature
can acts on hypothalamic neurons, but a permanent action on metabolic pathways can not be excluded.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Body weight; Capsaicin; Food intake
Elenco autori:
M. Falchi, A. Bertelli, F. Ferrara, R. Galazzo, S. Galazzo, C. Gharib, B. Dib
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