Perspective Chapter: Lipoprotein (a), Cardiac Amyloidosis, and Aortic Stenosis - Underestimated Associations
Capitolo
Data di Pubblicazione:
2022
Citazione:
Perspective Chapter: Lipoprotein (a), Cardiac Amyloidosis, and Aortic Stenosis - Underestimated Associations / G. Santangelo, N. Bernardi, A. Faggiano, A. Bonelli, F. Toriello, P. Faggiano, S. Carugo - In: Aortic Stenosis - Recent Advances, New Perspectives and Applications / [a cura di] P. Magnusson. - [s.l] : IntechOpen, 2022. - ISBN 978-1-78923-852-5. - pp. 1-24 [10.5772/intechopen.102902]
Abstract:
This chapter aims to address two peculiar aspects of pathophysiology and clinical
management of aortic valve stenosis, such as coexistence with cardiac amyloidosis and
association with lipoprotein (a). Calcific aortic valve stenosis is the most common heart
valve condition requiring surgical or transcatheter aortic valve replacement among
adults in Western societies. Lipoprotein (a) has been shown to play an important role in
the pathophysiological pathways leading to degenerative aortic stenosis, similar to that
in the pathogenesis of atherosclerosis. Studies are needed to verify whether therapies
that drastically reduce Lipoprotein (a) serum levels offer the possibility of a first medical
treatment to arrest the progression of aortic stenosis. A large percentage of patients with
aortic stenosis may have concomitant cardiac amyloidosis, commonly due to wild-type
transthyretin. The challenge in this context is to differentiate aortic stenosis alone from
aortic stenosis with cardiac amyloidosis, as cardiac amyloidosis shares several clinical,
electrocardiographic, and echocardiographic features with the aortic stenosis pheno-
type. Recognition of transthyretin-related amyloidosis prior to any type of intervention
is crucial for adequate risk stratification and to guide downstream management.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
aortic valve calcification; aortic valve stenosis; cardiac amyloidosis; lipoprotein (a); diagnostic imaging; drug therapy
Elenco autori:
G. Santangelo, N. Bernardi, A. Faggiano, A. Bonelli, F. Toriello, P. Faggiano, S. Carugo
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Titolo del libro:
Aortic Stenosis - Recent Advances, New Perspectives and Applications