Chiral fibers formation upon assembly of tetraphenylalanine peptide conjugated to a PNA dimer
Articolo
Data di Pubblicazione:
2022
Citazione:
Chiral fibers formation upon assembly of tetraphenylalanine peptide conjugated to a PNA dimer / A. Mosseri, M. Sancho-Albero, M. Leone, D. Nava, F. Secundo, D. Maggioni, L. De Cola, A. Romanelli. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - (2022). [Epub ahead of print] [10.1002/chem.202200693]
Abstract:
Self-assembly of biomolecules such as peptides, nucleic acids or their analogues affords supramolecular objects, exhibiting structures and physical properties dependent on the amino-acid or nucleobase composition. Conjugation of the peptide diphenylalanine (FF) to peptide nucleic acids triggers formation of self-assembled structures, mainly stabilized by interactions between FF. In this work we report formation of homogeneous chiral fibers upon self-assembly of the hybrid composed of the tetraphenylalanine peptide (4F) conjugated to the PNA dimer adenine-thymine (at). In this case nucleobases seem to play a key role in determining the morphology and chirality of the fibers. When the PNA "at" is replaced by guanine-cytosine dimer "gc", disordered structures are observed. Spectroscopic characterization of the self-assembled hybrids, along with AFM and SEM studies is reported. Finally, a structural model consistent with the experimental evidences has also been obtained, showing how the building blocks of 4Fat arrange to give helical fibers.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Peptide; Peptide Nucleic Acid; assembly; fiber; helix;
Elenco autori:
A. Mosseri, M. Sancho-Albero, M. Leone, D. Nava, F. Secundo, D. Maggioni, L. De Cola, A. Romanelli
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