Data di Pubblicazione:
2022
Citazione:
The multifaceted aspects of stress / P. Brivio. - In: PHARMADVANCES. - 4:2(2022 Aug), pp. 121-129. [10.36118/pharmadvances.2022.31]
Abstract:
The effects of stress depend on the nature and duration of the exposure, with the triggering of
molecular mechanisms that allow individuals to react to the stressful context. In particular, while
acute stress induces the activation of circuits to ensure normal homeostasis and mediates
adaptive responses, chronic stress exposure has detrimental and long-lasting effects on brain
unctions. Indeed, chronic stressful life events act as precipitating factors for many psychiatric
conditions, including major depressive disorders. In this context, it is worthy of mention that there
are differences in individual susceptibility, with some people displaying vulnerability to stressful
events and others being resilient to the same adversities. Moreover, exposure to chronic adverse
situations may leave permanent ‘scars’ in the individual, which confer enhanced vulnerability forrelapse since it is possible that not all the systems impaired by chronic stress are restored during
the remission.
On these bases, it is fundamental to better understand the behavioral outcomes of stressful
events as well as the molecular changes that may sustain them for the discovery of novel
therapeutic targets and approaches to treat stress-related disorders and to promote resilience.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
acute stress; chronic stress; resilience; HPA axis, Bdnf;
Elenco autori:
P. Brivio
Link alla scheda completa: