Le lipoproteine ad alta densità: uno strumento polivalente contro il cancro? = High density lipoproteins as a multitasking tool to fight cancer
Articolo
Data di Pubblicazione:
2021
Citazione:
Le lipoproteine ad alta densità: uno strumento polivalente contro il cancro? = High density lipoproteins as a multitasking
tool to fight cancer / A. Ossoli, M. Gomaraschi. - In: GIORNALE ITALIANO DELL'ARTERIOSCLEROSI. - ISSN 2240-4821. - 12:3(2021), pp. 19-30.
Abstract:
High density lipoproteins are well known for their cardioprotective role. Their ability to inhibit the
development and progression of atherosclerosis is likely due to their role in the reverse transport of
cholesterol from peripheral tissues to the liver for excretion and to their antioxidant and anti-inflammatory
properties. Since lipids, oxidative stress and inflammation can promote cancer cell proliferation,
HDL could affect tumor development and progression through the same mechanisms as well. Several
alterations of cellular metabolism, including those affecting cholesterol, are shared by many types of
cancers. Besides fatty acids, cholesterol and its metabolites were shown to play a key role in cancer cell
proliferation. In this context, when cancer cells are exposed to HDL, cholesterol content is reduced,
with an overall rewiring of cell metabolism. In addition, in vitro and in vivo studies showed that HDL
could limit the formation and availability of pro-oxidant and pro-inflammatory molecules in the tumor
microenvironment. Here, HDL can also promote immune surveillance and reduce angiogenesis. Finally,
HDL-like particles can be used as delivery agents for the selective uptake of antineoplastic agents
by cancer cells, thanks to their binding to the scavenger receptor BI. In this context, a key advantage
is that the delivery agent has an intrinsic antitumor activity per se, thus likely rendering cancer cells
more sensitive to antineoplastic agents.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
high density lipoproteins; cancer; tumor microenvironment; drug delivery;
Elenco autori:
A. Ossoli, M. Gomaraschi
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