Data di Pubblicazione:
2021
Citazione:
7-docosahexaenoyl-quercetin / S. Mazzotta, G. Carullo, F. Sciubba, M.E. Di Cocco, F. Aiello. - In: MOLBANK. - ISSN 1422-8599. - 2021:2(2021 Apr 15), pp. M1203.1-M1203.4. [10.3390/M1203]
Abstract:
Fatty acids and polyphenols represent different classes of pharmacologically active molecules. Hybrid derivatives of these compounds are interesting therapeutic tools. They could be obtained using enzymatic approaches, which allow regioselective derivatizations. In this short note, the pancreatic porcine lipase was employed to mediate the regioselective synthesis of 7-docosahexaenoylquercetin was described. The C-7 regioisomer formation was confirmed by 1H-NMR experiment. Generally, in this approach the alcoholic OH- was preferred when present. Nevertheless, in this case, it was demonstrated that the hindrance of the acyl group is a variable to obtain a good regioselectivity
in C-7 position, employing only one-step reaction.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
quercetin; DHA; lipase; regioselective; polyphenols
Elenco autori:
S. Mazzotta, G. Carullo, F. Sciubba, M.E. Di Cocco, F. Aiello
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