Herpes zoster and simplex reactivation following COVID-19 vaccination: new insights from a vaccine adverse event reporting system (VAERS) database analysis
Articolo
Data di Pubblicazione:
2022
Citazione:
Herpes zoster and simplex reactivation following COVID-19 vaccination: new insights from a vaccine adverse event reporting system (VAERS) database analysis / M. Gringeri, V. Battini, G. Cammarata, G. Mosini, G. Guarnieri, C. Leoni, M. Pozzi, S. Radice, E. Clementi, C. Carnovale. - In: EXPERT REVIEW OF VACCINES. - ISSN 1476-0584. - 21:5(2022 May 04), pp. 675-684. [10.1080/14760584.2022.2044799]
Abstract:
Background: A few cases of Herpes Zoster and Simplex reactivation following COVID-19 immunization have been recently described, but the real extent of this suspected adverse event has not been elucidated yet. Methods: We performed a nested case/control study by using the U.S. Vaccine Adverse Event Reporting System database. We carried out a case-level clinical review of all Herpes reactivation cases following the administration of COVID-19 vaccines. For cases and controls, significance was set at P = 0.05, differential risk of reporting was assessed for each vaccine as reporting odds ratio and incidence was estimated based on the total number of vaccine doses administered. Results: Of 6,195 cases included in the analysis (5,934 and 273 reporting Herpes Zoster and Herpes Simplex, respectively) over 90% were non-serious. We found a slightly higher risk of reporting both for Zoster (ROR = 1.49) and Simplex (ROR = 1.51) infections following the Pfizer-BioNTech vaccine. The estimated incidence was approximately 0.7/100,000 and 0.03/100,000 for Zoster and Simplex, respectively. Conclusions: The paucity of cases (almost all of non-serious nature) makes the potential occurrence of this adverse effect negligible from clinical standpoints, thus supporting the good safety profile of the COVID-19 vaccination, which remains strongly recommended.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
COVID-19; herpes; pharmacovigilance; real-world evidence; vaccines;
Elenco autori:
M. Gringeri, V. Battini, G. Cammarata, G. Mosini, G. Guarnieri, C. Leoni, M. Pozzi, S. Radice, E. Clementi, C. Carnovale
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