Data di Pubblicazione:
2022
Citazione:
Emerging mycotoxins and reproductive effects in animals : A short review / I. Chiminelli, L.J. Spicer, E.R.S. Maylem, F. Caloni. - In: JOURNAL OF APPLIED TOXICOLOGY. - ISSN 0260-437X. - (2022 Feb 28). [Epub ahead of print] [10.1002/jat.4311]
Abstract:
Emerging Fusarium mycotoxins beauvericin (BEA), enniatins (ENNs), and moniliformin (MON) are gaining increasing interest due to their wide presence especially in cereals and grain-based products. In vitro and in vivo studies indicate that Fusarium mycotoxins can be implicated in reproductive disorders in animals. Of these mycotoxins, BEA may affect reproductive functions, impairing the development of oocytes in pigs and sheep. Studies show dramatic inhibitory effects of BEA and ENNA on bovine granulosa cell steroidogenesis. ENNs also inhibit boar sperm motility and cause detrimental effects on embryos in mice and pigs. Although little data are reported on reproductive effects of MON, in vitro studies show inhibitory effects of MON on Chinese hamster ovary cells. The present review aims to summarize the reproductive toxicological effects of emerging Fusarium mycotoxins BEA, ENNs, and MON on embryo development, ovarian function, and testicular function of animals. In vitro and in vivo toxicological data are reported although additional studies are needed for proper risk assessment.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
beauvericin; enniatin; Fusarium mycotoxins; moniliformin; reproduction
Elenco autori:
I. Chiminelli, L.J. Spicer, E.R.S. Maylem, F. Caloni
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