Data di Pubblicazione:
2020
Citazione:
Gangliosides in podocyte biology and disease / B. Savas, G. Astarita, M. Aureli, D. Sahali, M. Ollero. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 21:24(2020), pp. 9645.1-9645.17. [10.3390/ijms21249645]
Abstract:
Gangliosides constitute a subgroup of glycosphingolipids characterized by the presence of sialic acid residues in their structure. As constituents of cellular membranes, in particular of raft microdomains, they exert multiple functions, some of them capital in cell homeostasis. Their presence in cells is tightly regulated by a balanced expression and function of the enzymes responsible for their biosynthesis, ganglioside synthases, and their degradation, glycosidases. The dysregulation of their abundance results in rare and common diseases. In this review, we make a point on the relevance of gangliosides and some of their metabolic precursors, such as ceramides, in the function of podocytes, the main cellular component of the glomerular filtration barrier, as well as their implications in podocytopathies. The results presented in this review suggest the pertinence of clinical lipidomic studies targeting these metabolites.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ceramide; Glomerulopathies; Glomerulus; Glycosphingolipids; Kidney; Nephrotic syndrome; Podocytopathies; Rafts; Animals; Cell Membrane; Gangliosides; Glomerular Filtration Barrier; Humans; Podocytes
Elenco autori:
B. Savas, G. Astarita, M. Aureli, D. Sahali, M. Ollero
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