Data di Pubblicazione:
2009
Citazione:
Antipsychotic drugs modulate Arc expression in the rat brain / F. Fumagalli, A. Frasca, G. Racagni, M.A. Riva. - In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. - ISSN 0924-977X. - 19:2(2009 Feb), pp. 109-115.
Abstract:
We found that, in the striatum, acute injections of the first generation
antipsychotic (FGA) haloperidol or the second generation antipsychotic (SGA)
olanzapine enhanced Arc mRNA levels, however such induction persisted for at
least 2 h in haloperidol-treated rats whereas it waned as early as 1 h after
olanzapine injection. Conversely, repeated injections led to a persistent
decrease of striatal Arc gene expression, regardless of the agent examined. In
the frontal cortex, acute injection of both antipsychotics caused a reduction of
Arc mRNA levels which persisted for at least 2 h. Following repeated treatment,
olanzapine reduced Arc mRNA levels 2 h, but not 24 h, post-treatment whereas
haloperidol was ineffective. Of note, the SGA quetiapine regulated the Arc gene
expression similarly to olanzapine. Given the particular nature of Arc, our
findings show its fine tuning following antipsychotic administration to be highly
dependent on the length of the treatment and on the brain region investigated and
suggest that antipsychotic drugs affect this marker of neuronal activity differently
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F. Fumagalli, A. Frasca, G. Racagni, M.A. Riva
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