Polystyrene perturbs the structure, dynamics, and mechanical properties of DPPC membranes: An experimental and computational study
Articolo
Data di Pubblicazione:
2022
Citazione:
Polystyrene perturbs the structure, dynamics, and mechanical properties of DPPC membranes: An experimental and computational study / D. Bochicchio, C. Laura, M. Vittoria Cadario, L. Palchetti, F. Natali, L. Monticelli, G. Rossi, E. DEL FAVERO. - In: JOURNAL OF COLLOID AND INTERFACE SCIENCE. - ISSN 0021-9797. - 605:(2022 Jan), pp. 110-119. [10.1016/j.jcis.2021.07.069]
Abstract:
Synthetic plastic oligomers can interact with the cells of living organisms by different ways. They can be
intentionally administered to the human body as part of nanosized biomedical devices. They can be
inhaled by exposed workers, during the production of multicomponent, polymer-based nanocomposites.
They can leak out of food packaging. Most importantly, they can result from the degradation of plastic
waste, and enter the food chain. A physicochemical characterization of the effects of synthetic polymers
on the structure and dynamics of cell components is still lacking. Here, we combine a wide spectrum of
experimental techniques (calorimetry, x-ray, and neutron scattering) with atomistic Molecular Dynamics
simulations to study the interactions between short chains of polystyrene (25 monomers) and model
lipid membranes (DPPC, in both gel and fluid phase). We find that doping doses of polystyrene oligomers
alter the thermal properties of DPPC, stabilizing the fluid lipid phase. They perturb the membrane structure and dynamics, in a concentration-dependent fashion. Eventually, they modify the mechanical properties of DPPC, reducing its bending modulus in the fluid phase. Our results call for a systematic,
interdisciplinary assessment of the mechanisms of interaction of synthetic, everyday use polymers with
cell membranes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Differential Scanning Calorimetry (DSC); Elastic Neutron Scattering (ENS); Lipid bilayer; Model membrane; Molecular dynamics (MD); Nanoplastics; Polystyrene; X-ray scattering;
Elenco autori:
D. Bochicchio, C. Laura, M. Vittoria Cadario, L. Palchetti, F. Natali, L. Monticelli, G. Rossi, E. DEL FAVERO
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