Data di Pubblicazione:
2021
Citazione:
Hyaluronic acid-dexamethasone nanoparticles for local adjunct therapy of lung inflammation / C.I. Camara, L. Bertocchi, C. Ricci, R. Bassi, A. Bianchera, L. Cantu', R. Bettini, E. Del Favero. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 22:19(2021 Sep 28), pp. 10480.1-10480.18. [10.3390/ijms221910480]
Abstract:
The delivery of a dexamethasone formulation directly into the lung appears as an appropriate strategy to strengthen the systemic administration, reducing the dosage in the treatment of lung severe inflammations. For this purpose, a hyaluronic acid-dexamethasone formulation was developed, affording an inhalable reconstituted nanosuspension suitable to be aerosolized. The physico-chemical and biopharmaceutical properties of the formulation were tested: size, stability, loading of the spray-dried dry powder, reconstitution capability upon redispersion in aqueous media. Detailed structural insights on nanoparticles after reconstitution were obtained by light and X-ray scattering techniques. (1) The size of the nanoparticles, around 200 nm, is in the proper range for a possible engulfment by macrophages. (2) Their structure is of the core-shell type, hosting dexamethasone nanocrystals inside and carrying hyaluronic acid chains on the surface. This specific structure allows for nanosuspension stability and provides nanoparticles with muco-inert properties. (3) The nanosuspension can be efficiently aerosolized, allowing for a high drug fraction potentially reaching the deep lung. Thus, this formulation represents a promising tool for the lung administration via nebulization directly in the pipe of ventilators, to be used as such or as adjunct therapy for severe lung inflammation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
drug delivery; light scattering; lung administration; mucus interaction; nanocrystals; nanoparticle characterization; X-ray scattering; Administration, Inhalation; aerosols; dexamethasone; humans; hyaluronic acid; nanoparticles; pneumonia
Elenco autori:
C.I. Camara, L. Bertocchi, C. Ricci, R. Bassi, A. Bianchera, L. Cantu', R. Bettini, E. Del Favero
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