Data di Pubblicazione:
1999
Citazione:
Equivalent radius of paracellular “pores” of the mesothelium / E. Agostoni, F. Bodega, L. Zocchi. - In: JOURNAL OF APPLIED PHYSIOLOGY. - ISSN 8750-7587. - 87:2(1999 Aug), pp. 538-544.
Abstract:
Diffusional permeability (P) to H2O, Cl- and mannitol was determined in specimens of rabbit parietal pericardium without and with phospholipids added on luminal side, as previously done with sucrose and Na+. P to above molecules and to Na+ was also determined after having scraped away mesothelium from specimens. Pw, PCl-, PNa+ and Pman of connective tissue were: (x 10-5 cm / s) 73.1 ± 7.3 (SE); 59.5 ± 4.5; 41.7 ± 3.4; 23.4 ± 2.4. From these and corresponding data on integer pericardium Pw, PCl-, PNa+ and Pman of mesothelium were computed. They were: (x 10-5 cm / s) 206; 17.9; 9.52; 3.93, and 90.2; 14.4; 4.34; 1.75, without and with phospholipids, respectively. As previously found for Psuc, P to solutes is smaller in mesothelium than in connective tissue, though the latter is about 35-fold thicker; instead, Pw is higher in mesothelium, suggesting marked water diffusion through cell membrane. Equivalent radius of paracellular “pores” of mesothelium was computed with 2 approaches, disregarding Pw. The former, a graphical analysis on P - molecular radius diagram, yielded 6.0 and 1.7 nm without and with phospholipids, respectively. The latter, based on Pman, Psuc and function for restricted diffusion, yielded 7.8 and 1.1 nm, respectively.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Connective tissue; Diffusional permeability to water and small solutes; Pericardium; Phospholipids
Elenco autori:
E. Agostoni, F. Bodega, L. Zocchi
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