Data di Pubblicazione:
1984
Citazione:
Hyper IgE syndrome: four case report / P. Pigatto, M.M. Polenghi, G.F. Altomare, A.M. Brugo, G.L. Tadini, M. Morelli. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - 63:4(1984 Sep), pp. 378-382.
Abstract:
Patients with hyper IgE syndrome (HIES) have varying degree of immunological unbalance that account for deficiency of total T and OKT8 lymphocytes. To investigate the role of immunostimulating drugs in HIES, thymostimulin (TP1) and levamisole were given in highly controlled groups of patients after a wash out period with disodium-chromoglycate (DSCG). Both drugs do not modify clinical picture whereas they do modulate some laboratory parameters as T lymphocyte total number, IgE plasmatic concentration, neutrophil chemotaxis. Furthermore TP1 had a worsening clinical effect in 3 of our patients. In our opinion we feel that the therapies proposed and employed so far for this rare disease must be critically analyzed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antibodies, Monoclonal; Chemotaxis, Leukocyte; Child; Humans; Hypergammaglobulinemia; Immunoglobulin E; Immunotherapy; Leukocyte Count; Levamisole; Thymus Extracts
Elenco autori:
P. Pigatto, M.M. Polenghi, G.F. Altomare, A.M. Brugo, G.L. Tadini, M. Morelli
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