Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors
Articolo
Data di Pubblicazione:
2021
Citazione:
Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors / K.-. Won, R. Heo, H.-. Park, B.K. Lee, F.Y. Lin, M. Hadamitzky, Y.-. Kim, J.M. Sung, E. Conte, D. Andreini, G. Pontone, M.J. Budoff, I. Gottlieb, E.J. Chun, F. Cademartiri, E. Maffei, H. Marques, P. de Araujo Goncalves, J.A. Leipsic, S.-. Lee, S. Shin, J.H. Choi, R. Virmani, H. Samady, K. Chinnaiyan, D.S. Berman, J. Narula, L.J. Shaw, J.J. Bax, J.K. Min, H.-. Chang. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 324:(2021 May), pp. 46-51. [10.1016/j.atherosclerosis.2021.03.009]
Abstract:
Background and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma atherogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA). Methods: A total of 1488 adults (60.9 ± 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concentrations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) ≥1.0%/year. All participants were divided into three groups based on AIP tertiles. Results: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02–2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV. Conclusions: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Atherogenic index of plasma; Atherosclerosis; Coronary artery disease; Coronary computed tomography angiography; Adult; Computed Tomography Angiography; Coronary Angiography; Female; Humans; Male; Risk Factors; Atherosclerosis; Coronary Artery Disease; Plaque, Atherosclerotic;
Elenco autori:
K.-. Won, R. Heo, H.-. Park, B.K. Lee, F.Y. Lin, M. Hadamitzky, Y.-. Kim, J.M. Sung, E. Conte, D. Andreini, G. Pontone, M.J. Budoff, I. Gottlieb, E.J. Chun, F. Cademartiri, E. Maffei, H. Marques, P. de Araujo Goncalves, J.A. Leipsic, S.-. Lee, S. Shin, J.H. Choi, R. Virmani, H. Samady, K. Chinnaiyan, D.S. Berman, J. Narula, L.J. Shaw, J.J. Bax, J.K. Min, H.-. Chang
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