Investigation of TNBC in vitro antiproliferative effects of versatile pirrolo[1,2-a]quinoxaline compounds
Articolo
Data di Pubblicazione:
2019
Citazione:
Investigation of TNBC in vitro antiproliferative effects of versatile pirrolo[1,2-a]quinoxaline compounds / M. Perri, F. Aiello, E. Cione, G. Carullo, L. Amendola, S. Mazzotta, M.C. Caroleo. - In: FRONTIERS IN MOLECULAR BIOSCIENCES. - ISSN 2296-889X. - 6(2019 Mar 12), pp. 12.1-12.5. [10.3389/fmolb.2019.00012]
Abstract:
The triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents an interesting field. In this context MDA- MB-231 cell line was selected to evaluate the antiproliferative effects of new [1,2-a]-pyrroloquinoxaline derivatives. The MTT assay revealed that the amine forms of synthesized molecules were more active compared to iminic ones at 72 h of incubation. The antiproliferative effect of the most promising compounds highlighted the formation of autophagic vacuoles.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antiproliferative activity; Autophagy; One-pot reaction; Pyrroloquinoxalines; Triple-negative breast cancer
Elenco autori:
M. Perri, F. Aiello, E. Cione, G. Carullo, L. Amendola, S. Mazzotta, M.C. Caroleo
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