Mantonico and pecorello grape seed extracts : Chemical characterization and evaluation of in vitro wound-healing and anti-inflammatory activities
Articolo
Data di Pubblicazione:
2020
Citazione:
Mantonico and pecorello grape seed extracts : Chemical characterization and evaluation of in vitro wound-healing and anti-inflammatory activities / G. Carullo, F. Sciubba, P. Governa, S. Mazzotta, L. Frattaruolo, G. Grillo, A.R. Cappello, G. Cravotto, M.E. Di Cocco, F. Aiello. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 13:5(2020), pp. 97.1-97.12. [10.3390/ph13050097]
Abstract:
The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable applications such as health-promoting properties are still under investigation. The seeds of the white berries of Mantonico and Pecorello cv. were extracted in a Soxhlet apparatus, using n-hexane and chloroform as solvents. Extracts were characterized by NMR and GC-MS analyses. They were assayed in vitro as wound healing and anti-inflammatory agents in HaCaT and RAW 264.7 cell lines, respectively. n-hexane Mantonico extract resulted in the most interesting wound healing sample, while n-hexane Pecorello, containing a good number of carotenoids, resulted in a good anti-inflammatory candidate. These preliminary findings underlined the benefit of grape seed extracts valorization due to their health-promoting properties.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Anti-inflammatory; Carotenoids; GC-MS; Grape seeds; HaCaT cell line; Lipophilic fraction; NMR; RAW 264.7 cell line; Soxhlet; Wound healing
Elenco autori:
G. Carullo, F. Sciubba, P. Governa, S. Mazzotta, L. Frattaruolo, G. Grillo, A.R. Cappello, G. Cravotto, M.E. Di Cocco, F. Aiello
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