Data di Pubblicazione:
2021
Citazione:
Pustular psoriasis : from pathophysiology to treatment / G. Genovese, C. Moltrasio, N. Cassano, C.A. Maronese, G.A. Vena, A.V. Marzano. - In: BIOMEDICINES. - ISSN 2227-9059. - 9:12(2021 Nov 23), pp. 1746.1-1746.22. [10.3390/biomedicines9121746]
Abstract:
Pustular psoriasis (PP) is a clinicopathological entity encompassing different variants, i.e., acute generalized PP (GPP), PP of pregnancy (impetigo herpetiformis), annular (and circinate) PP, infantile/juvenile PP, palmoplantar PP/palmoplantar pustulosis, and acrodermatitis continua of Hallopeau (ACH), which have in common an eruption of superficial sterile pustules on an erythematous base. Unlike psoriasis vulgaris, in which a key role is played by the adaptive immune system and interleukin (IL)-17/IL-23 axis, PP seems to be characterized by an intense inflammatory response resulting from innate immunity hyperactivation, with prominent involvement of the IL-36 axis. Some nosological aspects of PP are still controversial and debated. Moreover, owing to the rarity and heterogeneity of PP forms, data on prognosis and therapeutic management are limited. Recent progresses in the identification of genetic mutations and immunological mechanisms have promoted a better understanding of PP pathogenesis and might have important consequences on diagnostic refinement and treatment. In this narrative review, current findings in the pathogenesis, classification, clinical features, and therapeutic management of PP are briefly discussed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
acrodermatitis continua of Hallopeau; clinical features; generalized pustular psoriasis; impetigo herpetiformis; palmoplantar pustular psoriasis; palmoplantar pustulosis; pathogenesis; pustular psoriasis; therapy
Elenco autori:
G. Genovese, C. Moltrasio, N. Cassano, C.A. Maronese, G.A. Vena, A.V. Marzano
Link alla scheda completa: