Data di Pubblicazione:
2008
Citazione:
Regulation of DNA repair throughout the cell cycle / D. Branzei, M. Foiani. - In: NATURE REVIEWS. MOLECULAR CELL BIOLOGY. - ISSN 1471-0072. - 9:4(2008), pp. 297-308. [10.1038/nrm2351]
Abstract:
The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Branzei, M. Foiani
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