Atypical bacterial pathogens and small-vessel leukocytoclastic vasculitis of the skin in children: Systematic literature review
Articolo
Data di Pubblicazione:
2021
Citazione:
Atypical bacterial pathogens and small-vessel leukocytoclastic vasculitis of the skin in children: Systematic literature review / C. Betti, P. Camozzi, V. Gennaro, M.G. Bianchetti, M. Scoglio, G.D. Simonetti, G.P. Milani, S.A.G. Lava, A. Ferrarini. - In: PATHOGENS. - ISSN 2076-0817. - 10:1(2021 Jan), pp. 31.1-31.9. [10.3390/pathogens10010031]
Abstract:
Leukocytoclastic small-vessel vasculitis of the skin (with or without systemic involvement) is often preceded by infections such as common cold, tonsillopharyngitis, or otitis media. Our purpose was to document pediatric (≤18 years) cases preceded by a symptomatic disease caused by an atypical bacterial pathogen. We performed a literature search following the Preferred Reporting of Systematic Reviews and Meta-Analyses guidelines. We retained 19 reports including 22 cases (13 females and 9 males, 1.0 to 17, median 6.3 years of age) associated with a Mycoplasma pneumoniae infection. We did not find any case linked to Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetii, Francisella tularensis, or Legionella pneumophila. Patients with a systemic vasculitis (N = 14) and with a skin-limited (N = 8) vasculitis did not significantly differ with respect to gender and age. The time to recovery was ≤12 weeks in all patients with this information. In conclusion, a cutaneous small-vessel vasculitis with or without systemic involvement may occur in childhood after an infection caused by the atypical bacterial pathogen Mycoplasma pneumoniae. The clinical picture and the course of cases preceded by recognized triggers and by this atypical pathogen are indistinguishable.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Atypical pathogens; Chlamydophila pneumoniae; Chlamydophila psittaci; Coxiella burnetii; Francisella tularensis; Legionella pneumophila; Leukocytoclastic small-vessel vasculitis; Mycoplasma pneumoniae
Elenco autori:
C. Betti, P. Camozzi, V. Gennaro, M.G. Bianchetti, M. Scoglio, G.D. Simonetti, G.P. Milani, S.A.G. Lava, A. Ferrarini
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