Data di Pubblicazione:
2007
Citazione:
Hardwiring the brain: endocannabinoids shape neuronal connectivity / P. Berghuis, A.M. Rajnicek, Y.M. Morozov, R.A. Ross, J. Mulder, G.M. Urbán, K. Monory, G. Marsicano, M. Matteoli, A. Canty, A.J. Irving, I. Katona, Y. Yanagawa, P. Rakic, B. Lutz, K. Mackie, T. Harkany. - In: SCIENCE. - ISSN 0036-8075. - 316:5828(2007 May 25), pp. 1212-1216. [10.1126/science.1137406]
Abstract:
The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB1 cannabinoid receptors (CB1Rs) are enriched in the axonal growth cones of γ-aminobutyric acid-containing (GABAergic) interneurons in the rodent cortex during late gestation. Endocannabinoids trigger CB1R internalization and elimination from filopodia and induce chemorepulsion and collapse of axonal growth cones of these GABAergic interneurons by activating RhoA. Similarly, endocannabinoids diminish the galvanotropism of Xenopus laevis spinal neurons. These findings, together with the impaired target selection of cortical GABAergic interneurons lacking CB1Rs, identify endocannabinoids as axon guidance cues and demonstrate that endocannabinoid signaling regulates synaptogenesis and target selection in vivo.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P. Berghuis, A.M. Rajnicek, Y.M. Morozov, R.A. Ross, J. Mulder, G.M. Urbán, K. Monory, G. Marsicano, M. Matteoli, A. Canty, A.J. Irving, I. Katona, Y. Yanagawa, P. Rakic, B. Lutz, K. Mackie, T. Harkany
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