Directed Network Mapping Approach to Rotor Localization in Atrial Fibrillation Simulation
Contributo in Atti di convegno
Data di Pubblicazione:
2021
Citazione:
Directed Network Mapping Approach to Rotor Localization in Atrial Fibrillation Simulation / M. Vila, S. Rocher, M.W. Rivolta, J. Saiz, R. Sassi (ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). - In: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)[s.l] : IEEE, 2021. - ISBN 978-1-7281-1179-7. - pp. 730-733 (( Intervento presentato al 43. convegno Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) tenutosi a on line nel 2021 [10.1109/EMBC46164.2021.9629911].
Abstract:
Catheter ablation for atrial fibrillation (AF) is one of the most commonly performed electrophysiology procedures. Despite significant advances in our understanding of AF mechanisms in the last years, ablation outcomes remain suboptimal for many patients, particularly those with persistent or long-standing AF. A possible reason is that ablation techniques mainly focus on anatomic, rather than patient-specific functional targets for ablation. The identification of such ablation targets remains challenging. The purpose of this study is to investigate a novel approach based on directed networks, which allow the automatic detection of important arrhythmia mechanisms, that can be convenient for guiding the ablation strategy. The networks are generated by processing unipolar electrograms (EGMs) collected by the catheters positioned at the different regions of the atria. Network vertices represent the locations of the recordings and edges are determined using cross-covariance time-delay estimation method. The algorithm identifies rotational activity, spreading from vertex to vertex creating a cycle. This work is a simulation study and it uses a highly detailed computational 3D model of human atria in which sustained rotor activation of the atria was achieved. Virtual electrodes were placed on the endocardial surface, and EGMs were calculated at each of these electrodes. The propagation of the electric wave fronts in the atrial myocardium during AF is very complex, so in order to properly capture wave propagation patterns, we split EGMs into multiple short time frames. Then, a specific network for each of these time frames was generated, and the cycles repeating in consecutive networks point us to the stable rotor's location. The respective atrial voltage map served as reference. By detecting a cycle between the same 3 nodes in 19 out of 58 networks, where 10 of these networks were in consecutive time frames, a stable rotor was successfully located.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
Computer Simulation; Electrophysiologic Techniques, Cardiac; Heart Atria; Humans; Atrial Fibrillation; Catheter Ablation
Elenco autori:
M. Vila, S. Rocher, M.W. Rivolta, J. Saiz, R. Sassi
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Link al Full Text:
Titolo del libro:
2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)