Hypofractionated proton therapy in breast cancer: where are we? A critical review of the literature
Articolo
Data di Pubblicazione:
2022
Citazione:
Hypofractionated proton therapy in breast cancer: where are we? A critical review of the literature / D. Alterio, E. La Rocca, S. Volpe, A.M. Camarda, A. Casbarra, W. Russell-Edu, M.A. Zerella, R. Orecchia, V. Galimberti, P. Veronesi, M.C. Leonardi, B.A. Jereczek-Fossa. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 192:2(2022 Apr), pp. 249-263. [10.1007/s10549-022-06516-4]
Abstract:
Purpose: To critically review available literature on hypofractionated (≥ 3 Gy/fraction) proton therapy (PT) for breast cancer (BCa). Methods: A systematic screening of the literature was performed in April 2021 in compliance with the preferred reporting items for systematic reviews and meta-analyses recommendations. All full-text publication written in English were considered eligible. Acute and late toxicities, oncological outcomes and dosimetric features were considered for the analysis. Results: Twelve publications met the inclusion criteria; all studies but one focused on accelerated partial breast irradiation (APBI). Eleven works considered post-operative patients, one referred to ABPI as a curative-intent modality. The dosimetric profile of PT compared favorably with both photon-based 3D conformal and intensity-modulated techniques, while a more extended follow-up is warranted to fully assess both the long-term toxicities and the non-inferiority of oncological outcomes. Conclusion: Our work shows that results on PT for BCa are currently only available for APBI applications, with dosimetric analyses demonstrating a clear advantage over both 3D conformal and intensity modulated X-rays techniques, especially when ≥ 2 treatment fields were used. However, further evidence is needed to define whether such theoretical benefit translates into clinical improvements, especially in the long-term.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Accelerated partial breast irradiation; Breast cancer; Dosimetry; Proton therapy; Quality of life
Elenco autori:
D. Alterio, E. La Rocca, S. Volpe, A.M. Camarda, A. Casbarra, W. Russell-Edu, M.A. Zerella, R. Orecchia, V. Galimberti, P. Veronesi, M.C. Leonardi, B.A. Jereczek-Fossa
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