Mannose as a biomarker of coronary artery disease: Angiographic evidence and clinical significance
Articolo
Data di Pubblicazione:
2022
Citazione:
Mannose as a biomarker of coronary artery disease: Angiographic evidence and clinical significance / E. Ferrannini, N. Marx, D. Andreini, B. Campi, A. Saba, M. Gorini, G. Ferrannini, A. Milzi, M. Magnoni, A. Maseri, A.P. Maggioni, M. Burgmaier. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 346(2022 Jan 01), pp. 86-92. [10.1016/j.ijcard.2021.11.038]
Abstract:
Background: High mannose has previously associated with insulin resistance and cardiovascular disease (CVD). Our objective is to establish whether mannose is associated with anatomical evidence of coronary artery disease (CAD). Methods: Plasma mannose concentrations were measured by liquid chromatography/tandem mass spectrometry in a discovery cohort (n = 513) and a validation cohort (n = 221) of carefully phenotyped individuals. In both cohorts CAD was quantitated using state-of-the-art imaging techniques (coronary computed coronary tomography angiography (CCTA), invasive coronary angiography and optical coherence tomography). Information on subsequent CVD events/death was collected. Associations of mannose with angiographic variables and biomarkers were tested using univariate and multivariate regression models. Survival analysis was performed using the Kaplan-Meier estimator. Results: Mannose was related to indices of CAD and features of plaque vulnerability. In the discovery cohort, mannose was a marker of quantity and quality of CCTA-proven CAD and subjects with a mannose level in the top quartile had a significantly higher risk of CVD events/death (p = 3.6e-5). In the validation cohort, mannose was significantly associated with fibrous cap thickness < 65 μm (odds ratio = 1.32 per each 10 μmol/L mannose change [95% confidence interval, 1.05–1.65]) and was an independent predictor of death (hazard ratio for mannose≥vs < 84.6 μmol/L: 4.0(95%CI, 1.4–11.3), p = 0.006). Conclusion: The current data add novel evidence that high mannose is a signature of CAD with a vulnerable plaque phenotype, consistently across measures of severity of vessel involvement and independent of the traditional correlates of CVD, and that it is an independent predictor of incident adverse outcomes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Computed coronary tomography angiography; Coronary angiography; Coronary atherosclerosis; Optical coherence tomography; Plasma mannose; Risk assessment; Biomarkers; Computed Tomography Angiography; Coronary Angiography; Humans; Predictive Value of Tests; Prognosis; Risk Factors; Severity of Illness Index; Coronary Artery Disease; Mannose
Elenco autori:
E. Ferrannini, N. Marx, D. Andreini, B. Campi, A. Saba, M. Gorini, G. Ferrannini, A. Milzi, M. Magnoni, A. Maseri, A.P. Maggioni, M. Burgmaier
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