Data di Pubblicazione:
2009
Citazione:
Ariprazole in the treatment of Huntington's Disease. A case series / A. Ciammola, J. Sassone, C. Colciago, N.E. Mencacci, B. Poletti, A. Ciarmiello, F. Squitieri, V. Silani. - In: NEUROPSYCHIATRIC DISEASE AND TREATMENT. - ISSN 1176-6328. - 5:1(2009), pp. 1-4.
Abstract:
Objectives: The aim of the study was to describe the effects of aripiprazole, a new atypical antipsychotic drug that acts as a partial dopamine agonist on motor, behavioral and cognitive functions in patients with genetically confirmed Huntington's disease (HD). Methods and results: Three HD patients were evaluated for Unified Huntington Disease Rating Scale part I and II and Beck Depression Inventory at baseline, after two months and one-year treatment. Aripiprazole effectively controlled involuntary movements and psychiatric symptoms, with effects on cognitive functions. Conclusions: Our case reports suggest that aripiprazole is well tolerated, remarkably improving some of the motor and behavioral symptoms in patients affected by HD. Randomized, controlled, long-term studies are warranted.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Ciammola, J. Sassone, C. Colciago, N.E. Mencacci, B. Poletti, A. Ciarmiello, F. Squitieri, V. Silani
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