Data di Pubblicazione:
2009
Citazione:
First chemoenzymatic synthesis of immunomodulating macrolactam pimecrolimus / P. Ferraboschi, D. Colombo, M. De Mieri, P. Grisenti. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 50:30(2009 Jul 29), pp. 4384-4388. [10.1016/j.tetlet.2009.05.066]
Abstract:
The preparation of pimecrolimus, a synthetic derivative of ascomycin endowed with immunomodulatory activity, requires the selective protection of 24-hydroxy group of the ascomycin, before elaboration of the 32 one. The aim was achieved by means of two regioselective Candida antarctica lipase-catalyzed steps. The structure of the new key intermediates, 24-, 32-monoacetates and 24,32-diacetate, was established by means of an unambiguous NMR study.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ascomycin; Immunomodulator; Lipase; Macrolactam; Regioselectivity
Elenco autori:
P. Ferraboschi, D. Colombo, M. De Mieri, P. Grisenti
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