Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
Articolo
Data di Pubblicazione:
2021
Citazione:
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy / M.R. Ippolito, V. Martis, S. Martin, A.E. Tijhuis, C. Hong, R. Wardenaar, M. Dumont, J. Zerbib, D.C.J. Spierings, D. Fachinetti, U. Ben-David, F. Foijer, S. Santaguida. - In: DEVELOPMENTAL CELL. - ISSN 1534-5807. - 56:17(2021), pp. 2440-2454. [10.1016/j.devcel.2021.07.006]
Abstract:
Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells might exploit aneuploidy-induced genome instability and the resulting gene copy-number changes to survive under conditions of selective pressure, such as chemotherapy. Resistance to chemotherapeutic drugs was dictated by the acquisition of recurrent karyotypes, indicating that gene dosage might play a role in driving chemoresistance. Thus, our study establishes a causal link between aneuploidy-driven changes in gene copy number and chemoresistance and might explain why some chemotherapies fail to succeed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
aneuploidy; cancer; chemotherapy; drug resistance; genome instability; Chromosomal Instability; Drug Resistance; Gene Dosage; Genomic Instability; Humans; Karyotype; Aneuploidy; Drug Therapy
Elenco autori:
M.R. Ippolito, V. Martis, S. Martin, A.E. Tijhuis, C. Hong, R. Wardenaar, M. Dumont, J. Zerbib, D.C.J. Spierings, D. Fachinetti, U. Ben-David, F. Foijer, S. Santaguida
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