Lipase elevation in serum of COVID-19 patients : frequency, extent of increase and clinical value
Articolo
Data di Pubblicazione:
2022
Citazione:
Lipase elevation in serum of COVID-19 patients : frequency, extent of increase and clinical value / S. Caruso, E. Aloisio, A. Dolci, M. Panteghini. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - 60:1(2022), pp. 135-142. [10.1515/cclm-2021-0824]
Abstract:
Objectives: Previous studies reported lipase elevations in serum of COVID-19 patients trying to establish a causal link between SARS-CoV-2 infection and pancreatic damage. However, the degree and prevalence of hyperlipasemia was not uniform across studies.
Methods: We retrospectively evaluated 1,092 hospitalized patients with COVID-19 and at least one available lipase result. The number and frequency of patients with lipase above the upper reference limit (URL), >3 URL, and >6 URL were estimated. Correlations between lipase values and other biomarkers of organ or tissue damage were performed to identify possible extra-pancreatic sources of lipase release. The potential prognostic role of lipase to predict death and intensive care unit (ICU) admission during hospitalization was also evaluated.
Results: Lipase was >URL in 344 (31.5%) of COVID-19 patients. Among them, 65 (5.9%) and 25 (2.3%) had a peak lipase >3 URL and >6 URL, respectively. In the latter group, three patients had acute pancreatitis of gallstone or druginduced etiology. In others, the etiology of lipase elevations appeared multifactorial and could not be directly related to SARS-CoV-2 infection. No correlation was found between lipase and other tested biomarkers of organ and tissue damage. Lipase concentrations were not different between survivors and non-survivors; however, lipase was significantly increased (p<0.001) in patients admitted to the ICU, even if the odds ratio for lipase as predictor of ICU
admission was not significant.
Conclusions: Lipase was elevated in ∼1/3 of COVID-19 patients, but the clinical significance of this finding is unclear and irrelevant to patient prognosis during hospitalization.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
acute pancreatitis; COVID-19; lipase; SARS-CoV-2
Elenco autori:
S. Caruso, E. Aloisio, A. Dolci, M. Panteghini
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