Data di Pubblicazione:
2015
Citazione:
IL-10 critically modulates B cell responsiveness in Rankl-/- mice / V. Marrella, N. Lo Iacono, E. Fontana, C. Sobacchi, H. Sic, F. Schena, L. Sereni, M. Castiello, P. Poliani, P. Vezzoni, B. Cassani, E. Traggiai, A. Villa. - In: JOURNAL OF IMMUNOLOGY. - ISSN 0022-1767. - 194:9(2015), pp. 4144-4153. [10.4049/jimmunol.1401977]
Abstract:
The immune and the skeletal system are tightly interconnected, and B lymphocytes are uniquely endowed with osteo-interactive properties. In this context, receptor activator of NF-kappa B (RANK) ligand (RANKL) plays a pivotal role in lymphoid tissue formation and bone homeostasis. Although murine models lacking RANK or RANKL show defects in B cell number, the role of the RANKL-RANK axis on B physiology is still a matter of debate. In this study, we have characterized in detail B cell compartment in Rankl(-/-) mice, finding a relative expansion of marginal zone B cells, B1 cells, and plasma cells associated with increased Ig serum levels, spontaneous germinal center formation, and hyperresponse to CD40 triggering. Such abnormalities were associated with an increased frequency of regulatory B cells and augmented B cell-derived IL-10 production. Remarkably, in vivo IL-10-R blockade reduced T cell-triggered plasma cell differentiation and restrained the expansion of regulatory B cells. These data point to a novel role of the RANKL-RANK axis in the regulation of B cell homeostasis and highlight an unexpected link between IL-10 CD40 signaling and the RANKL pathway.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
V. Marrella, N. Lo Iacono, E. Fontana, C. Sobacchi, H. Sic, F. Schena, L. Sereni, M. Castiello, P. Poliani, P. Vezzoni, B. Cassani, E. Traggiai, A. Villa
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