Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water
Articolo
Data di Pubblicazione:
2013
Citazione:
Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water / V. Pace, L. Castoldi, A.R. Alcantara, W. Holzer. - In: RSC ADVANCES. - ISSN 2046-2069. - 3:26(2013 Apr 15), pp. 10158-10162. [10.1039/c3ra41262h]
Abstract:
A straightforward chromatography-free preparation of Weinreb amides starting from acid halides has been achieved in the biphasic medium 2-MeTHF/water. Analytically pure compounds were isolated in excellent yields simply after removal of 2-MeTHF, which absolutely avoids the use of any contaminant organic solvent within the whole process due to its (practically) immiscibility with water.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
V. Pace, L. Castoldi, A.R. Alcantara, W. Holzer
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