REGAZZONI LUCA GIOVANNI

Coffee silver skin as a source of polyphenols: high resolution mass spectrometric profiling of components and antioxidant activity.

2015

Abstract

The discovery of a carnosine derivative (FL-926-A16) as selective and efficient sequestering agent of cytotoxic carbonyl species : from molecular design to preclinical studies.

2011

Abstract

Top–down and bottom–up mass spectrometric analysis of covalent modifications of albumin cys34 as biomarker of oxidative stress.

2011

Abstract

In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism.

ANTIOXIDANTS.

2020

Academic Article

Open Access

Development and validation of a HPLC method for the direct separation of carnosine enantiomers and analogues in dietary supplements.

JOURNAL OF CHROMATOGRAPHY. B.

2019

Academic Article

Reserved Access

Development and validation of a sensitive LC–MS/MS assay for the quantification of anserine in human plasma and urine and its application to pharmacokinetic study.

AMINO ACIDS.

2019

Academic Article

Reserved Access

Differentially Expressed Proteins in Primary Endothelial Cells Derived From Patients With Acute Myocardial Infarction.

HYPERTENSION.

2019

Academic Article

Partially Open Access

Phenolic profile and biological activity of table grapes (Vitis vinifera L.).

BIO WEB OF CONFERENCES.

2019

Academic Article

Open Access

Phenolic profiles and anti-inflammatory activities of sixteen table grape (Vitis vinifera L.) varieties.

FOOD & FUNCTION.

2019

Academic Article

Mixed Access

Phenolic proﬁle and antioxidant activity of different grape (Vitis vinifera L.) varieties.

BIO WEB OF CONFERENCES.

2019

Academic Article

Pro-oxidant and pro-inflammatory effects of glycated albumin on cardiomyocytes.

FREE RADICAL BIOLOGY & MEDICINE.

2019

Academic Article

Open Access

Profiling Vaccinium macrocarpon components and metabolites in human urine and the urine ex-vivo effect on Candida albicans adhesion and biofilm-formation.

BIOCHEMICAL PHARMACOLOGY.

2019

Academic Article

Open Access

Ripe and Raw Pu-Erh Tea: LC-MS Profiling, Antioxidant Capacity and Enzyme Inhibition Activities of Aqueous and Hydro-Alcoholic Extracts.

MOLECULES.

2019

Academic Article

Open Access

The Disposal of Reactive Carbonyl Species Through Carnosine Conjugation : What We Know Now.

CURRENT MEDICINAL CHEMISTRY.

2019

Academic Article

Reserved Access

Tuning PFKFB3 Bisphosphatase Activity Through Allosteric Interference.

SCIENTIFIC REPORTS.

2019

Academic Article

Open Access

A carnosine analog mitigates metabolic disorders of obesity by reducing carbonyl stress.

THE JOURNAL OF CLINICAL INVESTIGATION.

2018

Academic Article

Open Access

Direct HPLC separation of carnosine enantiomers with two chiral stationary phases based on penicillamine and teicoplanin derivatives.

JOURNAL OF SEPARATION SCIENCE.

2018

Academic Article

Imine Deaminase Activity and Conformational Stability of UK114, the Mammalian Member of the Rid Protein Family Active in Amino Acid Metabolism.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.

2018

Academic Article

Open Access

Isotopic labelling for the characterisation of HNE-sequestering agents in plant-based extracts and its application for the identification of anthocyanidins in black rice with giant embryo.

FREE RADICAL RESEARCH.

2018

Academic Article

Reserved Access

MS methods to study macromolecule-ligand interaction : applications in drug discovery.

METHODS.

2018

Academic Article

Reserved Access

Preparation of enantiopure methionine, arginine, tryptophan, and proline benzyl esters in green ethers by Fischer–Speier reaction.

AMINO ACIDS.

2018

Academic Article

Reserved Access

Stressed degradation studies of domiphen bromide by LC-ESI-MS/MS identify a novel promising antimicrobial agent.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.

2018

Academic Article

Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob/ob Mice.

SCIENTIFIC REPORTS.

2017

Academic Article

Open Access

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

JOURNAL OF MEDICINAL CHEMISTRY.

2017

Academic Article

Reserved Access

Enzymatic and Non-Enzymatic Detoxification of 4-Hydroxynonenal : Methodological Aspects and Biological Consequences.

FREE RADICAL BIOLOGY & MEDICINE.

2017

Academic Article

Reserved Access

New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-κB transcription factors.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY.

2017

Academic Article

Open Access

Pharmacokinetic profile of bilberry anthocyanins in rats and the role of glucose transporters : LC-MS/MS and computational studies.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.

2017

Academic Article

Reserved Access

Using lysine adducts of human serum albumin to investigate the disposition of exogenous formaldehyde in human blood.

TOXICOLOGY LETTERS.

2017

Academic Article

Reserved Access

A carnosine intervention study in overweight human volunteers: Bioavailability and reactive carbonyl species sequestering effect.

SCIENTIFIC REPORTS.

2016

Academic Article

Open Access

Adductomics Pipeline for Untargeted Analysis of Modifications to Cys34 of Human Serum Albumin.

ANALYTICAL CHEMISTRY.

2016

Academic Article

Reserved Access

Coffee silver skin as a source of polyphenols : high resolution mass spectrometric profiling of components and antioxidant activity.

JOURNAL OF FUNCTIONAL FOODS.

2016

Academic Article

Reserved Access

Design, synthesis, and evaluation of acrylamide derivatives as direct NLRP3 inflammasome inhibitors.

CHEMMEDCHEM.

2016

Academic Article

Reserved Access

Screening of preservatives by HPLC-PDA-ESI/MS : a focus on both allowed and recently forbidden compounds in the new EU cosmetics regulation.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.

2016

Academic Article

Reserved Access

Serum albumin as a probe for testing the selectivity of irreversible cysteine protease inhibitors : the case of vinyl sulfones.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.

2016

Academic Article

Reserved Access

Set-up and application of an analytical approach for the quality control of purified colostrum as food supplement.

JOURNAL OF CHROMATOGRAPHY. B.

2016

Academic Article

Reserved Access

Establish an automated flow injection ESI-MS method for the screening of fragment based libraries : application to Hsp90.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES.

2015

Academic Article

Reserved Access

Guillain Barré syndrome (GBS) : new insights in the molecular mimicry between C. jejuni and human peripheral nerve (HPN) proteins.

JOURNAL OF NEUROIMMUNOLOGY.

2015

Academic Article

Reserved Access

Advanced glycation end products of beta2-microglobulin in uremic patients as determined by high resolution mass spectrometry.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.

2014

Academic Article

Reserved Access

Mass spectrometric strategies for the identification and characterization of human serum albumin covalently adducted by amoxicillin : ex vivo studies.

CHEMICAL RESEARCH IN TOXICOLOGY.

2014

Academic Article

Reserved Access

Online microreactor titanium dioxide rplc-ltq-orbitrap ms automated platform for shotgun analysis of (Phospho) proteins in human amniotic fluid.

CHROMATOGRAPHIA.

2014

Academic Article

Reserved Access

A rapid profiling of gallotannins and flavonoids of the aqueous extract of Rhus coriaria L. by flow injection analysis with high-resolution mass spectrometry assisted with database searching.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.

2013

Academic Article

Reserved Access

A sandwich ELISA for measuring benzo[a]pyrene–albumin adducts in human plasma.

ANALYTICAL BIOCHEMISTRY.

2013

Academic Article

Reserved Access

Human serum albumin cysteinylation is increased in end stage renal disease patients and reduced by hemodialysis : mass spectrometry studies.

FREE RADICAL RESEARCH.

2013

Academic Article

Reserved Access

Separation and characterisation of beta2-microglobulin folding conformers by ion-exchange liquid chromatography and ion-exchange liquid chromatography-mass spectrometry.

ANALYTICA CHIMICA ACTA.

2013

Academic Article

Reserved Access

Oxidative damage in human gingival fibroblasts exposed to cigarette smoke.

FREE RADICAL BIOLOGY & MEDICINE.

2012

Academic Article

Reserved Access

An integrated high resolution mass spectrometric and informatics approach for the rapid identification of phenolics in plant extract.

JOURNAL OF CHROMATOGRAPHY A.

2011

Academic Article

Reserved Access

Design, synthesis, ADME properties, and pharmacological activities of β-alanyl-D-histidine (D-carnosine) prodrugs with improved bioavailability.

CHEMMEDCHEM.

2011

Academic Article

Reserved Access

Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping.

BIOORGANIC & MEDICINAL CHEMISTRY.

2011

Academic Article

Mass Spectrometric Strategies and their Applications for Molecular Mass Determination of Recombinant Therapeutic Proteins.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY.

2011

Academic Article

Reserved Access

Screening of fibrillogenesis inhibitors of β2-microglobulin : integrated strategies by mass spectrometry capillary electrophoresis and in silico simulations.

ANALYTICA CHIMICA ACTA.

2011

Academic Article

Reserved Access

Urinary profile of methylprednisolone acetate metabolites in patients following intra-articular and intramuscular administration.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY.

2011

Academic Article

Reserved Access

A Combined High-Resolution Mass Spectrometric and in silico Approach for the Characterisation of Small Ligands of β2-Microglobulin.

CHEMMEDCHEM.

2010

Academic Article

Edaravone Inhibits Protein Carbonylation by a Direct Carbonyl-Scavenging Mechanism: Focus on Reactivity, Selectivity, and Reaction Mechanisms.

ANTIOXIDANTS & REDOX SIGNALING.

2010

Academic Article

Les Maitres de l'Orge : the Proteome Content of Your Beer Mug.

JOURNAL OF PROTEOME RESEARCH.

2010

Academic Article

Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans.

AMINO ACIDS.

2010

Academic Article

Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl species.

CHEMMEDCHEM.

2009

Academic Article

En bloc elution of proteomes from combinatorial peptide ligand libraries.

JOURNAL OF PROTEOMICS.

2009

Academic Article

Hemoglobin glutathionylation can occur through cysteine sulfenic acid intermediate : electrospray ionization LTQ-Orbitrap hybrid mass spectrometry studies.

JOURNAL OF CHROMATOGRAPHY. B.

2009

Academic Article

Protein carbonylation: 2,4-dinitrophenylhydrazine reacts with both aldehydes/ketones and sulfenic acids.

FREE RADICAL BIOLOGY & MEDICINE.

2009

Academic Article

A solid-phase extraction procedure coupled to 1H NMR, with chemometric analysis, to seek reliable markers of the botanical origin of honey.

ANALYTICA CHIMICA ACTA.

2008

Academic Article

Reserved Access

A tandem MS precursor-ion scan approsch to identify variable covalent modification of albumin Cys34 : a new tool for studyng vascular carbonylation.

JOURNAL OF MASS SPECTROMETRY.

2008

Academic Article

Albumin is the main nucleophilic target of human plasma : a protective role against pro-atherogenic electrophilic reactive carbonyl species?.

CHEMICAL RESEARCH IN TOXICOLOGY.

2008

Academic Article

Quenching of alpha,beta-unsaturated aldehydes by green tea polyphenols : HPLC-ESI-MS/MS studies.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.

2008

Academic Article

Glycyl-histidyl-lysine (GHK) is a quencher of alpha,beta-4-hydroxy-trans-2-nonenal: A comparison with carnosine. Insights into the mechanism of reaction by electrospray ionization mass spectrometry, H-1 NMR, and computational techniques.

CHEMICAL RESEARCH IN TOXICOLOGY.

2007

Academic Article

Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenal.

JOURNAL OF MASS SPECTROMETRY.

2006

Academic Article

Reserved Access

Maillard reaction products in honey: mechanism of formation, LC-MSn evidence and theoretical studies.

2008

Conference Poster

Development of two chromatographic methods for the characterization of table and wine grapes (Vitis vinifera L.).

2019

Document

Reserved Access

In vitro evaluation of the gastric anti-inflammatory activity of different grape varieties.

2019

Document

Open Access

Synthesis and application of isotope-labeled carnosine in LCMS/MS.

2019

Document

Open Access

Differentially Expressed Proteins in Pulmonary Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension.

2018

Document

Reserved Access

Mass Spectrometry-Based Label Free Quantitative Proteomics to study the effect of 3-PO in endothelial cells.

2018

Document

Reserved Access

Phenolic fingerprint of 16 different grape varieties by HPLC/DAD/ESI/MS.

2018

Document

Open Access

Phenolic profile of different table grape varieties characterized by HPLC/DAD/ESI/MS.

2018

Document

Open Access

Unexpected reactivity of the antiseptic domiphen bromide.

2017

Document

Reserved Access

Covalent modification of beta2-microglobulin induced by reactive carbonyl species : high resolution mass spectrometric studies.

2013

Document

Heteroaryl carnosine analogues: design, synthesis and carbonyl quenching activity.

2011

Document

Reserved Access

An integrated high resolution mass spectrometric and informatics approach for the rapid identification of flavonoids in plant extract.

2010

Document

Capillary electrophoresis, mass spectrometry and in silico studies : a multi disciplinary approach for drug discovery.

2010

Document

Covalent modifications of albumin cys34 as biomarker of mild oxidative stress.

2010

Document

A TANDEM MS PRECURSOR-ION SCAN APPROACH FOR THE IDENTIFICATION OF VARIABLE COVALENT MODIFICATION OF ALBUMIN CYS34 TO STUDY VASCULAR CARBONYLATION.

2007

Document

Carnosine phenyl derivatives as specific and efficient sequestering agents of cytotoxic Reactive Carbonyl Species (RCS).

2007

Document

Albumin is a protein target of 4-hydroxy-trans-2-nonenal in human serum: mass spectrometric identification of Lys199, His146 and Cys34 adducted peptides as potential biomarkers of carbonylation damage.

2006

Document

ESI-MS infusion in the development of carbonyl quenchers : a rapid and versatile tool to study reactivity, specificity and reaction mechanisms.

2006

Document

Mass spectrometric identification of albumin as a protein target of 4-hydroxy-trans-2-nonenal in human serum: a potential biomarker of carbonilation damage?.

2006

Document

Mass spectrometry to study reactivity, specificity and reaction mechanism of new carbonyl quenchers.

2006

Document

POST TRANSLATIONAL OXIDATIVE MODIFICATIONS OF ALBUMIN AS POTENTIAL BIOMARKERS FOR THE EARLY DIAGNOSIS OF CARDIOVASCULAR DISEASES AND AS A TOOL TO EVALUATE THE EFFICACY OF REACTIVE CARBONYL SPECIES SEQUESTERING AGENTS.

2009

Thesis