A Tiered Approach to Systemic Toxicity Testing for Agricultural Chemical Safety Assessment
Academic Article
Publication Date:
2006
Citation:
A Tiered Approach to Systemic Toxicity Testing for Agricultural Chemical Safety Assessment / J.E. Doe, A.R. Boobis, A. Blacker, V. Dellarco, N.G. Doerrer, C. Franklin, J.I. Goodman, J.M. Kronenberg, R. Lewis, E.E. McConnell, T. Mercier, A. Moretto, C. Nolan, S. Padilla, W. Phang, R. Solecki, L. Tilbury, B. Van Ravenzwaay, D.C. Wolf. - In: CRITICAL REVIEWS IN TOXICOLOGY. - ISSN 1040-8444. - 36:1(2006), pp. 37-68. [10.1080/10408440500534370]
abstract:
Aproposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical
Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved
approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies
are scientifically appropriate and necessary without being redundant, and that tests emphasize
toxicological endpoints and exposure durations that are relevant for risk assessment. The ACSA
Systemic Toxicity Task Force proposes an approach to systemic toxicity testing as one part of the
overall assessment of a compound’s potential to cause adverse effects on health. The approach is
designed to provide more relevant data for deriving reference doses for shorter time periods of
human exposure, and includes fewer studies for deriving longer term reference doses—that is,
neither a 12-month dog study nor a mouse carcinogenicity study is recommended. All available
data, including toxicokinetics and metabolism data and life stages information, are taken into
account. The proposed tiered testing approach has the potential to provide new risk assessment
information for shorter human exposure durations while reducing the number of animals used
and without compromising the sensitivity of the determination of longer term reference doses.
Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved
approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies
are scientifically appropriate and necessary without being redundant, and that tests emphasize
toxicological endpoints and exposure durations that are relevant for risk assessment. The ACSA
Systemic Toxicity Task Force proposes an approach to systemic toxicity testing as one part of the
overall assessment of a compound’s potential to cause adverse effects on health. The approach is
designed to provide more relevant data for deriving reference doses for shorter time periods of
human exposure, and includes fewer studies for deriving longer term reference doses—that is,
neither a 12-month dog study nor a mouse carcinogenicity study is recommended. All available
data, including toxicokinetics and metabolism data and life stages information, are taken into
account. The proposed tiered testing approach has the potential to provide new risk assessment
information for shorter human exposure durations while reducing the number of animals used
and without compromising the sensitivity of the determination of longer term reference doses.
IRIS type:
01 - Articolo su periodico
List of contributors:
J.E. Doe, A.R. Boobis, A. Blacker, V. Dellarco, N.G. Doerrer, C. Franklin, J.I. Goodman, J.M. Kronenberg, R. Lewis, E.E. Mcconnell, T. Mercier, A. Moretto, C. Nolan, S. Padilla, W. Phang, R. Solecki, L. Tilbury, B. Van Ravenzwaay, D.C. Wolf
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